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group 2020 spring

90 manuscripts,  https://orcid.org/0000-0003-0099-460X; citations >8100; Hirsch number (H-factor) is 44; 23 papers cited >100 times; 9 cited >200 X; 6 cited >300 X; 2 cited >500 X; 1 cited >1300 X; July 2020.

7 selected key original publications in the last 6 years: (S: first or last author)

Tait C, Chinnaiya K, Manning E, Murtaza M, Ashton JP, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS, Furley A, Rashbass P, Das RM, Storey KG, Placzek M (2020) Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal. Plos Biology 18:e3000470

Quinn PM* & Buck TM*, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J (2019) Human iPSC-derived retinas recapitulate the fetal CRB1 CRB2 complex formation an demonstrate that photoreceptors and Müller glia are targets of AAV5. Stem Cell Reports 12:906-919. S * first 2 authors equal contribution

Quinn PM, Mulder AA, Alves CH, Desrosiers M, Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J (2019) Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype. Hum Mol Genet 28:105-123 S

Quinn PM, Alves CH, Klooster J, Wijnholds J (2018) CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function. Hum Mol Genet 27:3137-3153 S

Talib M, van Schooneveld MJ, van Genderen MM, Wijnholds J, Florijn RJ, Ten Brink JB, Schalij-Delfos NE, Dagnelie G, Cremers FP, Wolterbeek R, Fiocco M, Thiadens AA, Hoyng CB, Klaver CC, Bergen AA, Boon CJ (2017) Genotypic and Phenotypic Characteristics of CRB1-Associated Retinal Dystrophies: A Long-Term Follow-up Study. Ophthalmology 124:884-895.

Ramkumar N, Omelchenko T, Silvia-Gagliardi NF, McGlade CH, Wijnholds J, Anderson KV (2016) Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol 18:1281-1291

Pellissier LP, Quinn PM, Alves CH, Vos RM, Klooster J, Flannery JG, Heimel JA, Wijnholds J (2015) Gene Therapy into Photoreceptors and Muller Glial Cells Restores Retinal Structure and Function in CRB1 Retinitis Pigmentosa Mouse Models. Hum Mol Genet 24:3104-3118 S

Selected publications in high impact journals: (S: first or last author)

Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van der Valk M, Krimpenfort P, Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3, 1275-1279 [2019 5y-IF 36.2] S

Ramkumar N, Omelchenko T, Silvia-Gagliardi NF, McGlade CH, Wijnholds J, Anderson KV (2016) Crumbs promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol 18:1281-1291 [2019 5y-IF 21.0]

Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho S-H, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84 [2019 5y-IF 16.0]

Wijnholds J, de Lange EC, Scheffer GL, van den Berg DJ, Mol CA, van d V, Schinkel AH, Scheper RJ, Breimer DD, Borst P (2000) Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105, 279-285 [2019 5y-IF 13.93] S

Wijnholds J, Scheffer GL, van der Valk M, van der Valk P, Beijnen JH, Scheper RJ, Borst P (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med 188, 797-808 [2019 5y-IF 11.98] S

 Zelcer N, van de Wetering K, de Waart R, Scheffer G, Marschall HU, Wielinga P, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Oude Elferink R, Borst P (2006) Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but display altered hepatic transport of endogenous glucuronides. J Hepatology 44:768-75 [2019 5y-IF 15.83]

Alves CH, Pellissier LP, Wijnholds J (2014) The CRB1 and adherens junction complex proteins in retinal development and maintenance. Prog Retin Eye Res 40:35-42 [2019 5y-IF 14.38] S

Borst P, Evers, R, Kool M, Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302 [2019 5y-IF 14.53] S

Reid G, Wielinga P, Zelcer N, van dH I, Kuil A, de Haas M, Wijnholds J, Borst P (2003) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100, 9244-9249 [2019 5y-IF 10.62]

Wijnholds J, Mol CA, Van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P (2000) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97, 7476-7481 [2019 5y-IF 10.62] S

van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der PT, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP, Borst P (1999) Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc Natl Acad Sci USA 96, 11501-11506 [2019 5y-IF 10.62]

Wijnholds J, Philipsen JN, AB G (1988) Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J 7, 2757-2763 [2019 5y-IF 10.37] S

 All publications:

Citation report

H-index:                                            44. With 22 manuscripts cited >100 times; 8>200x; 6>300x; 2>500x; 1>1300x

Number of publications:               90 plus 9 book chapters and 1 edited book

Sum of the times cited:                >8100

Average citations per item:         91 by 90 peer reviewed publications

Number of first authorships:      13 (of which 1 as co-first author)

Number of last authorships:       39

Number of co-authorships:         47

 

Peer-reviewed journal articles 

90Buck TM, Wijnholds J (2020) Recombinant Adeno-Associated Viral vectors (rAAV)-vector elements in ocular gene therapy clinical trials and transgene expression and bioactivity assays. Int J Mol Sci 21:4197 [2019 5y-IF 4.65] S

89Tait C, Chinnaiya K, Manning E, Murtaza M, Ashton JP, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS, Furley A, Rashbass P, Das RM, Storey KG, Placzek M (2020) Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal. Plos Biology 18:e3000470  [2019 5y-IF 8.87]

88Nguyen XT, Talib M, Nguyen XT, Talib M, van Cauwenbergh C, van Schooneveld MJ, Fiocco M, Wijnholds J, Ten Brink JB, Florijn RJ, Schalij-Delfos NE, Dagnelie G, van Genderen MM, de Baere E, Meester-Smoor MA, De Zaeytijd J, Balikova I, Thiadens AA, Hoyng CB, Klaver CC, van den Born LI, Bergen AA, Leroy BP, Boon CJF (2020) Clinical characteristics and natural history of RHO-associated retinitis pigmentosa: A long-term follow-up study. Retina In Press doi: 10.1097/IAE.0000000000002808 [2019 5y-IF 3.76]

87►Nguyen XT, Talib M, van Schooneveld MJ, Brinks J, Ten Brink J, Florijn RJ, Wijnholds J, Verdijk RM, Bergen AA, Boon CJF (2020) RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features. Int J Mol Sci 21:835 [2019 5y-IF 4.65] 

86Quinn PM*, Buck TM*, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J (2019) Human iPSC-derived retinas recapitulate the fetal CRB1 CRB2 complex formation an demonstrate that photoreceptors and Müller glia are targets of AAV5. Stem Cell Reports 12:906-919 [2019 5y-IF 6.62]  S * first two authors equal contribution

85Quinn PM, Wijnholds J (2019) Retinogenesis of the human fetal retina: An apical polarity perspective. Genes 10:987 [2019 5y-IF 3.82] S

84Alves CH, Boon N, Mulder AA, Koster AJ, Jost CR, Wijnholds J (2019) CRB2 loss in rod photoreceptors is associated with progressive loss of retinal contrast sensitivity. Int J Mol Sci 20:4069 [2019 5y-IF 4.65] S

83Wijnholds J  (2019) "Basal Cell Migration" in Regeneration of the Corneal Wound-Bed. Stem Cell Reports 12:3-5[2019 5y-IF 6.62]S

82Quinn PM, Mulder AA, Alves CH, Desrosiers M, de Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J (2019) Loss of CRB2 in Muller glial cells modifies a CRB1 associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype. Hum Mol Genet 28: 105-123 [2019 5y-IF 5.36] S

81Quinn PM, Alves CH, Klooster J, Wijnholds J (2018) CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function. Hum Mol Genet 27:3137-3153 [2019 5y-IF 5.36] S

80Talib M, van Schooneveld MJ, Thiadens AA, Fiocco M, Wijnholds J, Florijn RJ, Schalij-Delfos NE, van Genderen MM, Putter H, Cremers FPM, Dagnelie G, Ten Brink JB, Klaver CCW, van den Born LI, Hoyng CB, Bergen AA, Boon CJF (2019) Clinical and genetic characteristics of male patients with RPGR-associated retinal dystrophies: A Long-Term Follow-up Study. Retina 39:1186-1199 [2019 5y-IF 3.76]

79Talib M, van Schooneveld MJ, Van Cauwenbergh C, Wijnholds J, ten Brink JB, Florijn RF, Schalij-Delfos NE, Dagnelie G, van Genderen MM, de Zaeytijd J, Cremers FPM, van den Born LI, Thiadens AA, Hoyng CB, Klaver CC, Leroy BP, Bergen AA, Boon CJF (2018) The spectrum of structural and functional abnormalities in female carriers of pathogenic variants in the RPGR gene. Invest Ophthalmol Vis Sci 59:4123-4133 [2019 5y-IF 3.65]

             78Hoek RM, Quinn PM, Hooibrink B, Wijnholds J (2018) Transplantation of NTPDase2-positive sorted Müller glial into the mouse retina. J Neurosci Neurosurg 1(5):122 S

77Hoek RM, Quinn PM, Alves CH, Hooibrink B, Wijnholds J (2018) NTPDase2 as a surface marker to isolate flow cytometrically a Müller glial cell enriched population from dissociated neural retinae. J Neurosci Neurosurg 1(4):117 S

76Quinn PM, Pellissier LP, Wijnholds J (2017) The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy. Front Neurosci 11:175 [2019 5y-IF 4.23] S

75Dudok JJ, Leonards PEG, Wijnholds J (2017) Genetic and Molecular Approaches to study neuronal migration in the developing cerebral cortex. Brain Sci 7:pii: E53 [2019 IF 3.33] S

74Talib M, van Schooneveld MJ, van Genderen MM, Wijnholds J, Florijn RJ, Ten Brink JB, Schalij-Delfos NE, Dagnelie G, Cremers FP, Wolterbeek R, Fiocco M, Thiadens AA, Hoyng CB, Klaver CC, Bergen AA, Boon CJ (2017) Genotypic and Phenotypic Characteristics of CRB1-Associated Retinal Dystrophies: A Long-Term Follow-up Study. Ophthalmology 124:884-895 [2019 5y-IF 8.33]

73Ramkumar N, Omelchenko T, Silvia-Gagliardi NF, McGlade CH, Wijnholds J, Anderson KV (2016) Crumbs promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol 18:1281-1291 [2019 5y-IF 20.69]

72Dudok JJ, Murtaza M, Alves CH, Rashbass P, Wijnholds J (2016) Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res 108:12-23 [2019 5y-IF 2.40] S

71Ramkumar N, Harvey BM, Lee JD, Alcorn HL, Silva-Gagliardi NF, McGlade CJ, Bestor TH, Wijnholds J, Haltiwanger RS, Anderson KV (2015) Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet 11: e1005551 [2019 5y-IF 5.85]

70Pellissier LP, Quinn PM, Alves CH, Vos RM, Klooster J, Flannery JG, Heimel JA, Wijnholds J (2015) Gene Therapy into Photoreceptors and Muller Glial Cells restores Retinal Structure and Function in CRB1 Retinitis Pigmentosa Mouse Models. Hum Mol Genet 24:3104-3118 [2019 5y-IF 5.36] S

69Zhao M, Andrieu-Soler, Kowalczuk L, Paz Cortés M, Berdugo M, Dernigoghossian M, Halili F, Jeanny JC, Goldenberg B, Savoldelli M, El Sanharawi M, Naud MC, van Ijcken W, Pescini-Gobert R, Martinet D, Maass A, Wijnholds J, Crisanti P, Rivolta C, Behar-Cohen F (2015) A new CRB1 rat mutation links Muller glial cells to retinal telangiectasia. J Neurosci 35:6096-6106 [2019 5y-IF 6.33]

68Alves CH, Pellissier LP, Vos RM, Garcia Garrido M, Sothilingam V, Seide C, Beck SC, Klooster J, Flannery JG, Verhaagen J, Rashbass P, Seeliger MW, Wijnholds J (2014) Targeted ablation of Crb2 in photoreceptor cells induces Retinitis Pigmentosa. Hum Mol Genet 23:3384-401 [2019 5y-IF 5.36] S

67Pellissier LP, Lundvig DMS, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J (2014) CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice. Hum Mol Genet 23:3759-71 [2019 5y-IF 5.36] S

66Alves CH, Pellissier LP, Wijnholds J (2014) The CRB1 and adherens junction complex proteins in retinal development and maintenance. Prog Retin Eye Res 40:35-42 [2019 5y-IF 14.38] S

65Pellissier LP, Hoek RM, Vos RM, Aartsen WM, Klimczak RR, Verhaagen J, Flannery JG, Wijnholds J (2014) Specific Tools for Targeting Mouse and Human Müller Glial Cells. Mol Ther Methods Clin Dev 1:14009 [2019 5y-IF 3.81] S

64Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DMS, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia-Garrido M, Le Bivic A, Seeliger MW, Wijnholds J (2013) Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis. PLoS Genet 9:e1003976 [2019 5y-IF 5.85] S

63Alves CH, Bossers K, Vos RM, Essing AHW, Swagemakers S, van der Spek PJ, Verhaagen J, Wijnholds J (2013) Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PloS ONE 8(12):e82532 [2019 5y-IF 3.22] S

62Dudok JJ, Sanz AS, Lundvig DMS, Sothilingam V, Garcia-Garrido M, Klooster J, Seeliger MW, Wijnholds J (2013) MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Muller glia cells. Glia 61:1629-44 [2019 5y-IF 6.13] S

61Assémat E, Crost E, Ponserre M, Wijnholds J, Le Bivic A, Massey-Harroche D. (2013) The Multi-Pdz Domain Protein-1 (Mupp-1) Expression Regulates Cellular Levels Of The Pals-1/Patj Polarity Complex. Exp Cell Res 319:2514-25 [2019 5y-IF 3.36]

60Dudok JJ, Sanz AS, Lundvig DMS, Wijnholds J (2013) MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. J Neurosci 33:8518-27 [2019 5y-IF 6.33] S

59Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia-Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J (2013) Loss of CRB2 in the mouse retina mimics human Retinitis Pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22:35-50 [2019 5y-IF 5.36] S

58Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW, Wijnholds J (2011) PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J Neurosci 31:17230-17241 [2019 5y-IF 6.33] S

57Aartsen WM, van Cleef KWR, Pellissier L, Hoek RM, Vos RM, Blits B, Ehlert EME, Balaggan KS, Ali RR, Verhaagen J, Wijnholds J (2010) GFAP-driven transgene expression in activated Müller glial cells following intravitreal injection of AAV2/6 vectors. PLoS One 5:e12387 [2019 5y-IF 3.22] S

56Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho S-H, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84 [2019 5y-IF 15.99]

55Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessle A, Szurman P, Wolfrum U, Wijnholds J, Fisher MD, Humphries P, Seeliger MW (2010) Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol 248:1063-70 [2019 5y-IF 2.25]

54Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW (2009) Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One 4:e7507 [2019 5y-IF 3.22]

53Stöhr H, Heisig JB, Milenkovic V, Strauss O, Benz1 PM, Aartsen WM, Wijnholds J, Weber BHF, Schulz HL (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci 29:6809-18 [2019 5y-IF 6.33]

52Aartsen WM, Arsanto J-P, Chauvin J-P, Vos RM, Versteeg I, Nunes Cardozo B, Le Bivic A, Wijnholds J (2009) PSD95β regulates plasma membrane Ca(2+) pump localization at the photoreceptor synapse. Mol Cell Neurosci 41:156-65 [2019 5y-IF 3.16] S

51de Wolf C, Jansen R, Yamaguchi H, de Haas M, van de Wetering K, Schinkel A, Wijnholds J, Beijen J, Borst P (2008) Contribution of the drug transporter ABCG2 (Breast Cancer Resistance Protein) to resistance against anti-cancer nucleosides. Mol Cancer Therapeutics 7:3092-102 [2019 5y-IF 5.76]

50Van de Pavert SA, Sanz AS, Aartsen WM, Vos RM, Versteeg I, Beck SC, Klooster J, Seeliger MW, Wijnholds J (2007) Crb1 is a determinant of retinal apical Mueller glia cell features. Glia 55(14):1486-97 [2019 5y-IF 6.13] S

49Van de Pavert SA, Meuleman J, Malysheva A, Aartsen WM, Versteeg I, Tonagel T, Kamphuis W, McCabe CJ, Seeliger MW, Wijnholds J (2007) A single amino acid substitution (Cys249Trp) in the sixth epidermal growth factor (EGF) domain of Crb1 causes retinal degeneration and deregulates expression of Pituitary tumor transforming gene 1 (Pttg1). J Neurosci 27:564-573 [2019 5y-IF 6.33] S

48de Wolf CJF, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P (2007) cGMP transport by vesicles from human and mouse erythrocytes. FEBS J 274:439-450 [2019 5y-IF 4.26]

47Gavarini S, Becamel C, Altier C, Lory P, Poncet J, Wijnholds J, Bockaert J, Marin P (2006) Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-HT2C receptor desensitization and membrane stability. Mol Biol Cell 17: 4619-4631 [5y-IF 4.1]

46van Rossum AG, Aartsen WM, Meuleman J, Klooster J, Malysheva A, Versteeg I, Arsanto J-P, Le Bivic A, Wijnholds J (2006) Pals1/Mpp5 is required for correct localization of Crb1 at the sub-apical region in polarized Müller glia cells. Hum Mol Genet 15 :2659-72 [2019 5y-IF 5.36] S

45Richard M, Roepman R, Aartsen WM, van Rossum AG, den Hollander AI, Knust E, Wijnholds J, Cremers FP (2006) Towards understanding CRUMBS function in retinal dystrophies. Hum Mol Genet 15: R235-R243 [2019 5y-IF 5.36]

44Aartsen WM, Kantardzhieva A, Klooster J, van Rossum AG van de Pavert SA, Versteeg I, Nunes Cardozo B, Tonagel F, Beck SC, Tanimoto N, Seeliger MW, Wijnholds J (2006) Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum Mol Genet 15:1291-302 [2019 5y-IF 5.36] S

43Kantardzhieva A, Alexeeva S, Versteeg I, Wijnholds J (2006) MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. FEBS J 273:1152-1165 [2019 5y-IF 4.26] S

42Minich T, Riemer J, Schultz JB, Wielinga P, Wijnholds J, Dringen R (2006) The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem 97:373-384 [2019 5y-IF 4.35]

41Zelcer N, van de Wetering K, de Waart R, Scheffer G, Marschall HU, Wielinga P, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Oude Elferink R, Borst P (2006) Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but display altered hepatic transport of endogenous glucuronides. J Hepatology 44:768-75 [2019 5y-IF 15.83]

40Seeliger MW, Beck S, Pereyra-Muñoz N, Dangel S, Tsai J-Y, Luhmann U, van de Pavert S, Wijnholds J, Samardzija M, Wenzel A, Zrenner E, Fahl E, Tanimoto N, Acar N, Tonagel F (2005) In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res 45:3512-9 [2019 5y-IF 2.35]

39Michel D, Arsanto JP, Massey-Harroche D, Beclin C, Wijnholds J, Le Bivic A (2005) PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci 118:4049-57 [2019 5y-IF 4.90]

38Kantardzhieva A, Gosens I, Alexeeva S, Punte IM, Versteeg I, Krieger E, Neefjes-Mol CA, den Hollander AI, Letteboer SJF, Klooster J, Cremers FPM, Roepman R, Wijnholds J (2005) MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci 46:2192-201 [2019 5y-IF 3.65] S

37Wielinga P, Hooijberg JH, Gunnarsdottir G, Kathmann I, Reid R, Zelcer N, van der Born K, de Haas M, van der Heijden I, Kaspers G, Wijnholds J, Jansen G, Peters G, Borst P (2005) The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res 65:4425-30 [2019 5y-IF 9.88]

36Meuleman J, van de Pavert S, Wijnholds J (2004) Crumbs homologue 1 in polarity and blindness. Biochem Soc Trans 32, 828-830 [2019 5y-IF 3.98] S

35van de Pavert S, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger M, Rashbass P, Le Bivic A, Wijnholds J (2004) Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci 117, 4169-4177 [2019 5y-IF 4.90] S

34Borst P, Balzarini J, Ono N, Reid G, de Vries H, Wielinga P, Wijnholds J, Zelcer N (2004) The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy. Antiviral Res 62, 1-7 [2019 5y-IF 3.89]

33Hu X, Plomp A, Wijnholds J, Ten Brink J, van Soest S, van den Born LI, Leys A, Peek R, de Jong PT, Bergen AA (2003) ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum. Eur J Hum Genet 11, 215-224 [2019 5y-IF 3.78]

32Hu X, Plomp AS, van Soest S, Wijnholds J, de Jong PT, Bergen AA (2003) Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update. Surv Ophthalmol 48, 424-438 [2019 5y-IF 4.03]

31Reid G, Wielinga P, Zelcer N, de Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P (2003) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol 63, 1094-1103 [2019 5y-IF 3.90]

30Reid G, Wielinga P, Zelcer N, van dH I, Kuil A, de Haas M, Wijnholds J, Borst P (2003) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100, 9244-9249 [2019 5y-IF 10.62]

29Wielinga PR, van der Heijden I, Reid G, Beijnen JH, Wijnholds J, Borst P (2003) Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 278, 17664-17671 [2019 5y-IF 4.27]

28Wielinga PR, Reid G, Challa EE, van dH I, Van Deemter L, de Haas M, Mol C, Kuil AJ, Groeneveld E, Schuetz JD, Brouwer C, De Abreu RA, Wijnholds J, Beijnen JH, Borst P (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 62, 1321-1331 [2019 5y-IF 3.90]

27den Hollander AI, Ghiani M, de Kok YJ, Wijnholds J, Ballabio A, Cremers FP, Broccoli V (2002) Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev 110, 203-207 [2019 5y-IF 1.98]

26Scheffer GL, Hu X, Pijnenborg AC, Wijnholds J, Bergen AA, Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest 82, 515-518 [2019 5y-IF 4.41]

25ten Hove T, Drillenburg P, Wijnholds J, Te Velde AA, van Deventer SJ (2002) Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. Dig Dis Sci 47, 2056-2063 [2019 5y-IF 2.79]

24Schultz MJ, Wijnholds J, Peppelenbosch MP, Vervoordeldonk MJ, Speelman P, van Deventer SJ, Borst P, van der Poll PT (2001) Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J Immunol 166, 4059-4064 [2019 5y-IF 5.05]

23Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der LM, de Vree JM, van der Valk M, Elferink RP, Borst P, Scheper RJ (2000) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60, 5269-5277 [2019 5y-IF 9.88]

22Allen JD, Brinkhuis RF, Van Deemter L, Wijnholds J, Schinkel AH (2000) Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res 60, 5761-5766 [2019 5y-IF 9.88]

21Wijnholds J, de Lange EC, Scheffer GL, van den Berg DJ, Mol CA, van d V, Schinkel AH, Scheper RJ, Breimer DD, Borst P (2000) Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105, 279-285 [2019 5y-IF 13.93] S

20Wijnholds J, Mol CA, Van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P (2000) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97, 7476-7481 [2019 5y-IF 10.62] S

19Borst P, Evers R, Kool M, Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302 [2019 5y-IF 14.53] S

18Borst P, Evers R, Kool M, Wijnholds J (1999) The multidrug resistance protein family. Biochim Biophys Acta 1461, 347-357 [2019 5y-IF 8.18] S

17van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der PT, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP, Borst P (1999) Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc Natl Acad Sci USA 96, 11501-11506 [2019 5y-IF 10.62]

16Allen JD, Brinkhuis RF, Wijnholds J, Schinkel AH (1999) The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res 59, 4237-4241 [2019 5y-IF 9.88]

15Wijnholds J, Scheffer GL, van der Valk M, van der Valk P, Beijnen JH, Scheper RJ, Borst,P (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med 188, 797-808 [2019 5y-IF 11.98] S

14Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van der Valk M, Krimpenfort P, Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3, 1275-1279 [2019 5y-IF 36.23] S

13Evers R, Cnubben NH, Wijnholds J, Van Deemter L, van Bladeren PJ, Borst P (1997) Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS Lett 419, 112-116 [2019 5y-IF 3.37]

12Smidt MP, Russchen B, Snippe L, Wijnholds J, AB G (1995) Cloning and characterisation of a nuclear, site specific ssDNA binding protein. Nucleic Acids Res 23, 2389-2395 [2019 5y-IF 11.79]

11Wijnholds J, Chowdhury K, Wehr R, Gruss P (1995) Segment-specific expression of the neuronatin gene during early hindbrain development. Dev Biol 171, 73-84 [2019 5y-IF 3.08] S

10Smidt MP, Wijnholds J, Snippe L, van Keulen G, AB G (1994) Binding of a bZip protein to the estrogen-inducible apoVLDL II promoter. Biochim Biophys Acta 1219, 115-120 [2019 5y-IF 4.00]

9Chalepakis G, Wijnholds J, Giese P, Schachner M, Gruss P (1994) Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol 13, 891-900 [2019 5y-IF 2.90] co-S

8Chalepakis G, Wijnholds J, Gruss P (1994) Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains. Nucleic Acids Res 22, 3131-3137 [2019 5y-IF 11.79]

7Wijnholds J, Philipsen S, Pruzina S, Fraser P, Grosveld F, AB G (1993) Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res 21, 1629-1635 [2019 5y-IF 11.79] S

6Chalepakis G, Stoykova A, Wijnholds J, Tremblay P, Gruss P (1993) Pax: gene regulators in the developing nervous system. J Neurobiol 24, 1367-1384 [5y-IF 3.77]

5Calkhoven CF, AB G and Wijnholds J (1992) c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family. Nucleic Acids Res 20, 4093 [2019 5y-IF 11.79] S

4Wijnholds J, Muller E, AB G (1991) Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo. Nucleic Acids Res 19, 33-41 [2019 5y-IF 11.79] S

3Beekman JM, Wijnholds J, Schippers IJ, Pot W, Gruber M, AB G (1991) Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. Nucleic Acids Res 19, 5371-5377 [2019 5y-IF 11.79]

2Wijnholds J, Philipsen JN, AB G (1988) Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J 7, 2757-2763 [2019 5y-IF 10.37] S

1Smit MJ, Wijnholds J, Duursma AM, Bouma JM, Gruber M (1986) Plasma clearance of mitochondrial aspartate aminotransferase in the rat: competition with mitochondrial malate dehydrogenase. Biomed Biochim Acta 45, 1557-1561

Books 

1Boon, CJF, Wijnholds, J (Eds.) Retinal Gene Therapy (2018) Methods and Protocols. Springer ISBN 978-1-4939-7522-8 S

Book Chapters 

9Alves CH, Wijnholds J (2019) Microglial cell dysfunction in CRB1-associated retinopathies. Adv Exp Med Biol 1185:159-163 S

8Alves CH, Wijnholds J (2018) AAV-Mediated Gene Therapy for CRB1-Hereditary Retinopathies. IntechOpen DOI: 10.5772/intechopen.79308 S

7Buck TM, Pellissier LP, Vos RM, van Dijk EHC, Boon CJF, Wijnholds J (2018) AAV Serotype Testing on Cultured Human Donor Retinal Explants. Methods Mol Biol 1715:275-288 S

6Quinn PM, Buck TM, Ohonin C, Mikkers HMM, Wijnholds J (2018) Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays. Methods Mol Biol 1715:261-273 S

5Alves CH, Wijnholds J (2018) AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa. Methods Mol Biol 1715:135-151 S

4Verhaagen J, Hol EM, Huitenga I, Wijnholds J, Bergen AB, Boer GJ, Swaab DF (2008) Neurotherapy: Progress in restorative neuroscience and neurology. Elsevier ISBN: 978-0-12-374511-8.

3Wijnholds J (2006). Multidrug Resistance Proteins and efflux of organic anions at the blood-brain and blood cerebrospinal fluid barriers. Chapter in “Multidrug Resistance-Associated Proteins” by Aiello, C.V. (Nova Science Publishers; ISBN: 1-60021-298-0) S

2Wijnholds J (2005). Multidrug Resistance Proteins and efflux of organic anions at the blood-brain and blood cerebrospinal fluid barriers. Chapter in “Efflux Transporters and the Blood-Brain Barrier” by Taylor, E.M. (Nova Science Publishers; ISBN: 1-59454-625-8 ) S

1Wijnholds J (2002) Drug resistance caused by multidrug resistance-associated proteins. Novartis Found Symp 243, 69-79 S

 

Thesis


Wijnholds,J. Liver-specific regulation of the oestrogen-inducible apoVLDL II gene. University of Groningen, 1991. (PhD thesis)

 

Thesis of supervised PhD students:

Kantardzhieva, Albena. Crumbs and MAGUK proteins, from interaction to function. University of Amsterdam, 2006. (PhD thesis)

Alves, Celso Henrique Freitas. The Crumbs Complex in the Retina, from animal models to function. VU University Amsterdam, 2014 (PhD thesis)

Quinn, Peter M. The Retinal Crumbs Complex: From Animal Models and Retinal Organoids to Therapy. Leiden University Medical Center, 2019 (PhD thesis)